Please visit Google Scholar for a full list of Sellers Lab publications.

Selected key publications:

Li R, Klingbeil O, Monducci D, …, Ito T*, Sellers WR*. Comparative optimization of combinatorial CRISPR screens. Nat Commun. 2022. PDF

Ito T, Young MJ, Li R, …, Sellers WR. Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers. Nat Genet. 2021. PDF

Mulvaney KM, Blomquist C, Acharya N, …, Sellers WR. Molecular basis for substrate recruitment to the PRMT5 methylosome. Mol Cell. 2021 Aug; PDF

McKinney DC, McMillan BJ, Ranaghan MJ, …, Sellers WR*, Ianari A*. Discovery of a First-in-Class Inhibitor of the PRMT5–Substrate Adaptor Interaction. J Med Chem. 2021 Aug; PDF

Atack TC*, Raymond DD, Blomquist CA, …, Sellers WR*. Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35. ACS Med Chem Lett. 2020, 11, 2131−2138. PMID: 33209191. PDF

Zamanighomi M†, Jain SS†, Ito T, …, Sellers WR. GEMINI: a variational Bayesian approach to identify genetic interactions from combinatorial CRISPR screens. Genome Biol. 2019 Jul 12;20(1):137. PMID: 31300006. PDF

Ghandi M†, Huang FW†, Jané-Valbuena J, …, Garraway LA*, Sellers WR*. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature. 2019 May;569:503-508 PMID: 31068700. PDF

Li H, Ning S, Ghandi M, Kryukov GV, …, Schreiber SL, Clish CB, Garraway LA, Sellers WR. The landscape of cancer cell line metabolism. Nat Med. 2019 May;25(5):850-860. PMID: 31068703. PDF

McDonald ER 3rd†, de Weck A†, Schlabach MR†, Billy E*, …, Hofmann F*, Schmelzle T*, Sellers WR*. Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening. Cell. 2017 Jul 27;170(3):577-592. PMID: 28753431. PDF

Wylie AA, Schoepfer S, Jahnke W, …, Sellers WR. The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL. Nature. 2017 Mar 30;543:733-737. PMID: 28329763. PDF

Chen YP, LaMarche MJ, Chan H, …, Sellers WR*, Stams T*, Fortin PD*. Allosteric inhibition of SHP2 inhibits the transformed phenotype of RTK driven cancers. Nature. 2016;535:148-152 PMID: 27362227. PDF

Mavrakis KJ†, McDonald III ER†, Schlabach MR†, Billy E†, Hoffman GR†, …, Keen N, Schmelzle T, Hofmann F, Stegmeier F*, Sellers WR *. Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5. Science. 2016 Mar 11;351(6278):1208-13. PMID: 26912361. PDF

Gao H†, Korn JM†, Ferretti S, …, Williams JA* & Sellers WR*. High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response. Nat Med. 2015 Oct 19. PMID: 26479923. PDF

Barretina J†, Caponigro G†, Stransky N, …, Sellers WR*, Schlegel R*, Garraway LA*.The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012 Mar 28;483:603-7. PMCID: PMC3320027. PDF

Beroukhim R†, Lin M†, Park Y, Hao K, …, Sellers WR*, Li C*. Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays. PLoS Comput Biol. 2006 May;2(5):e41. PMID: 16699594. PDF

Garraway LA, Widlund HR, Rubin MA, …, Sellers WR. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature. 2005 Jul 7;436(7047):117-22. PMID: 16001072. PDF

Paez JG†, Jänne PA†, Lee JC†, …, Sellers WR*, Johnson BE*, Meyerson M*. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004 Jun 4;304(5676):1497-500. PMID: 15118125. PDF

Majumder PK, Febbo PG, Bikoff R, …, Sellers WR. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med. 2004 Jun;10(6):594-601. PMID: 15156201. PDF

Singh D†, Febbo PG†, Ross K, …, Golub TR*, Sellers WR*. Gene expression correlates of clinical prostate cancer behavior. Cancer Cell. 2002 Mar;1(2):203-9. PMID: 12086878. PDF

† These authors contributed equally

* These authors co-directed the work

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